Plasma colchicine concentration in patients with recurrent polyserositis (familial mediterranean fever) on long-term prophylaxis
نویسندگان
چکیده
منابع مشابه
Long-term colchicine prophylaxis in familial Mediterranean fever.
Abnormal skeletal development has occurred in chick embryos exposed to this agent and transplacentally acquired tetracycline has produced appreciable inhibition of fetal growth in rats.3 Chromosomal aberrations and a reduction in the mitotic index have been found on adding tetracycline to human lymphocyte cultures4 and in premature infants transient inhibition of skeletal growth has been observ...
متن کاملPatient with Recurrent Polyserositis (Familial Mediterranean Fever).
Familial Mediterranean fever (FMF) is a hereditary autosomal recessive ,systemic, auto-inflammatory disorder characterized by sporadic, unpredictable attacks of fever and serosal inflammation. FMF is caused by mutations in MEFV, a gene located on the short arm of chromosome 16 (16p13) which encodes a protein 'Pyrin'. The disorder has been given various names including familial paroxysmal polyse...
متن کاملColchicine concentration in leukocytes of patients with familial Mediterranean fever.
Free and total plasma, granulocyte and mononuclear cell colchicine concentrations were measured by radioimmunoassay in 30 patients with familial Mediterranean fever treated with colchicine 0.5 to 2 mg day-1. Colchicine concentrations showed a large intersubject variability in plasma (0.13-1.75 ng ml-1), granulocytes (4 to 64 ng/10(9) cells), and mononuclear cells (11.4 to 57.6 ng/10(9) cells). ...
متن کاملGenetic Analysis of Southwestern Iranian Patients with Familial Mediterranean Fever
Background: Familial Mediterranean fever (FMF) is an autosomal recessive genetic disorder characterized by recurrent episodes of self-limited fever and serosal tissues inflammation. Methods: To evaluate clinical symptoms and common genetic mutations in southwestern Iranian patients with FMF, 20 unrelated patients were enrolled in this study based on clinical criteria. A panel of 12 common ME...
متن کاملtreatment of colchicine-resistant familial mediterranean fever with anakinra
conclusions this case showed the effect of additional anakinra on children with fmf who were colchicine resistant. case presentation herein was reported a colchicine non-responsive patient with accurate diagnosis and early treatment of fmf. she had presented with recurrent and persistent acute abdominal pain attacks and several abdominal surgeries. addition of recombinant interleukin-1 receptor...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1982
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780250219